A number of reports over the past few years have presented data suggesting that a significant proportion of life science research is not reproducible. These reports suggest that as much as 50-70% of academic life science research cannot be reproduced and this is costing hundreds of millions of pounds on the generation of questionable data, which is hampering the success of translational research which leads to successful healthcare outcomes.
This has led Journals and funders to request more information for publications and grant requests on the authentication and validation of cell lines and other key biologicals and reagents.
For example, the National Institutes of Health (NIH) have published new guidelines for funding - NOT-OD-16-011 - Implementing Rigor and Transparency in NIH & AHRQ Research Grant Applications. These contain a new section of guidelines ‘Authentication of Key Biological and/or Chemical Resources’, which asks the funding requester to describe methods to ensure the identity and validity of key biological and/or chemical resources used in the proposed studies. As stated in the new guidelines ‘these include, but are not limited to, cell lines, specialty chemicals, antibodies, and other biologics’. Similarly, an increasing number of journals, including most cancer journals, are insisting on evidence of cell line authentication as a pre-requisite of publication.
The Culture Collections offer a range of validated products and services which will help academic life science researchers generate more robust reproducible research data. ECACC can test cell lines to ensure that they are not misidentified, cross contaminated, or differ genetically from the original stocks. For further information refer to the cell line authentication services pages on our website.
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