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The rise of iPSCs

iPSC Scientific literature graph

Figure 1: Number of publications citing the term 'iPSC'. Data sourced from Google Scholar

 

Induced pluripotent stem cells (iPSCs) are increasingly being used in research. The number of publications citing the use of iPSCs is increasing every year as seen in Figure 1 above.

To assist scientists in their research, ECACC provide quality-controlled and disease-relevant iPSC lines for academic, not-for-profit and commercial laboratories worldwide. The two iPSC collections distributed by ECACC are the HipSci collection and the EBiSC collection. These resources provide researchers with a choice of over 1,500 iPSC lines derived from blood and tissue samples, from male and female subjects of various ages, and represent a wide variety of rare and more prevalent diseases. 

Below is a selection of recent publications that have cited the use of iPSC lines avaiable from the HipSci and EBiSC collections via the ECACC catalogue. 

Year  Publication 
2019 The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients.
2019 Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
2019 The Academic Pill: How Academia Contributes to Curing Diseases.
2019 Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification.
 2019 Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.
 2019 Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity.
2019 CRISPR/Cas9-mediated one step bi-allelic change of genomic DNA in iPSCs and human RPE cells in vitro with dual antibiotic selection.
2019 Genetic effects on promoter usage are highly context-specific and contribute to complex traits.
2019 Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs.
2018 Gene expression variability across cells and species shapes innate immunity.
2018 BioSamples database: an updated sample metadata hub.
2018 RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.
2018 The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
2018 The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.

 

To keep up to date with with new iPSCs added to the collections check the ECACC New Cell Lines page and sign up to receive ECACC news and developments.

 

Prepared by Sharon Bahia.

 

October 2019

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