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Culture Collections

Public Health England has transferred the manufacture and supply of NCTC/NCPF Certified Reference Materials (CRMs) in LENTICULE® disc format to Sigma-Aldrich

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Public Health England (PHE) has transferred the manufacture and supply of bacterial and fungal NCTC/NCPF Certified Reference Materials (CRM) in LENTICULE disc format to Sigma-Aldrich.  This licensing agreement enables PHE to focus on product research and development while Sigma-Aldrich makes the reference materials readily available to end users worldwide.

The NCTC/NCPF CRMs are used as controls in food, water, environmental and clinical testing microbiology laboratories. Each CRM LENTICULE disc consists of a stipulated level of a pure culture of viable bacteria or fungi in a control-dried water-soluble matrix.  The bacterial and fungal strains are prepared directly from strains selected from PHE’s National Collection of Type Cultures (NCTC) and National Collection of Pathogenic Fungi (NCPF).  This means end users can be confident of using control organisms that are only a single subculture (passage) from the parent reference strain and are of known authenticity and quality.  NCTC and NCPF are part of the Culture Collections maintained by PHE which is committed to providing biological resources that support meaningful and reproducible laboratory results that are essential for protecting and improving people’s health.      

"Our agreement with Sigma-Aldrich will enable more scientists worldwide to easily access the NCTC/NCPF CRMs," said Julie Russell, Head of PHE’s Culture Collections. "Licensing the LENTICULE disc technology to Sigma-Aldrich means the PHE microbiologists can concentrate on the development of new products to improve health outcomes while end users benefit from Sigma-Aldrich’s expertise in manufacturing and global distribution."

The CRMs are being produced in accordance with ISO Guide 34 and individually packed for customer convenience at Sigma-Aldrich. “We have invested in a new dedicated Bio Safety Level 2 facility and expanded the scope of our ISO 17025/ ISO Guide 34 accreditation to manufacture this product range in full accordance with our Environmental Health and Safety (EHS) and quality guidelines,” said Fabian Wahl, Ph.D., Business Development Director at Sigma-Aldrich.

Visit the LENTICULE disc listings on the Sigma-Aldrich website


Please note the Norovirus and Hepatitis A virus LENTICULE discs continue to be available from Public Health England; these are not transferring to Sigma-Aldrich. You can browse and search the NCTC LENTICULE® disc collection.



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